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Adonat® Premium SAMe

Adonat® Premium SAMe

Gnosis’ Adonat® Premium SAMe is the only branded S-Adenosyl-L-methionine (SAMe) ingredient worldwide. SAMe is a naturally occurring molecule known for its role in supporting mood, emotional well-being, and cognitive function by influencing neurotransmitter methylation. It participates in over a hundred biochemical pathways and offers benefits for liver and joint health.


Adonat® Premium SAMe, with over 30 years of expertise and 10 patents, utilizes advanced manufacturing techniques, innovation, and rigorous research to create proprietary stabilized salts and innovative oral dosage forms.


SAMe is a critical player in methylation, a process vital for DNA, RNA, protein, hormone, cell membrane, myelin sheath, neurotransmitter synthesis, and modulation of physiological functions like inflammation, tissue repair, detoxification, and energy production. Additionally, it plays a crucial role in producing the master antioxidant, glutathione, which supports anti-inflammatory processes and redox balance.


Supplementing with SAMe can comprehensively address brain health by impacting neurotransmission, neuroprotection, and neuroplasticity. Moreover, it contributes to maintaining joint and liver health while countering compromised functions. SAMe is a versatile molecule, backed by evidence, that offers multifaceted benefits for overall well-being.

  • Generic and alternative names

    S-Adenosyl-L-methionine (SAMe)

  • Claims / benefits / efficacy


    • Highest Content of Active SAMe
    • EU Manufacturing Production
    • The One & Only Branded SAMe in Worldwide Market 
    • Traceable Supply Chain & Value-Chain Transparency 
    • More Than 10 Granted Patents
    • Customized Services & Co-branding Marketing 
    • Environmentally responsible brand 

    Brain health:

    • Enhances cell membrane function and integrity
    • Restores cellular membrane fluidity
    • Improves nerve cell communication
    • Supports neurotransmitter function
    • Involved in the synthesis of mood-affecting neurotransmitters
    • Age-related cognitive decline linked to SAMe deficiency


    • Implicated in longevity and aging processes
    • Influences DNA methylation
    • Supports antioxidant production
    • Affects gene expression and DNA repair

    Liver health:

    • Controls vital hepatic functions
    • Protects the liver from toxic agents and oxidative stress
    • Critical for glutathione production, a hepatoprotective agent

    Joint health:

    • Promotes healthy joints
    • Enhances cartilage regeneration and chondrocyte activity
    • Exhibits anti-inflammatory properties
    • May reduce pain through increased proteoglycan production
  • Function

    Active ingredient

  • Application

    • Stabilized fine powder with improved organoleptic properties, suitable for capsules, powder blends & mixes, sachets & sticks.
    • Conventional enteric coating, in different dosages and combinations for better absorption.
    • Stabilized fine granules with improved handling and gliding, suitable for blends & mixes, sachets & sticks.
    • Slow-release essential coating, with clean and minimal consumer- friendly excipients for better absorption.
  • Packaging

    5 kg / Made to Stock

  • Certifications & compliance

    • Gluten-free
    • Halal
    • Kosher
    • Lactose-free
    • Non GMO
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