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Avicel® DG

Avicel® DG

Microcrystalline Cellulose, NF, Ph. Eur., JP

and Anhydrous Dibasic Calcium Phosphate, USP, FCC, Ph. Eur., JP

Avicel DG is a proprietary co-spray dried MCC/DCP excipient optimized for the use in dry granulation processes. The unique characteristics of Avicel DG facilitate solid dosage form manufacturing utilizing roller compaction by improving process robustness, tablet hardness, and yields. Avicel DG offers good flow characteristics, high quality initial compactability, required for the production of robust ribbons, and excellent recompactability, resulting in enhanced tabletting performance and fewer rejected tablets.

  • Generic and alternative names

    • Avicel® DG Microcrystalline Cellulose and Anhydrous Dibasic Calcium Phosphate
    • Microcrystalline cellulose (INCI Name): MCC, cellulose gel;

    • Dicalcium phosphate anhydrous: calcium phosphate dibasic, phosphoric acid calcium salt, dicalcium orthophosphate, calcium hydrogen orthophosphate, calcium hydrogen phosphate, calcium monohydrogen phosphate

  • Claims / benefits / efficacy

    • Excellent compactibility and re-compactibility for difficult to compress formulations or dry granulation processes
    • Powder flow
    • Content uniformity
    • Tablet compactibility
    • Lubrication tolerance
    • Sensory attributes in chewables
    • Suspension properties in liquids
    • Highly suitable for continuous manufacturing
  • Function

    • Filler
    • Diluent
  • Application

    Key applications:

    • Direct-compression tableting

    • Dry granulation

    • Wet granulation

    • Extrusion and spheronization

    • Suspension

  • Grades

    Available Grades Particle Size, μm Moisture, % Differentiating Features
    Avicel® DG 45 NMT 5.0 Improved compactibility, mainly in dry granulation
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