Avicel® HFE-102
Microcrystalline Cellulose, NF, Ph. Eur., JP and mannitol, USP, Ph. Eur., JP
Avicel® HFE-102 is a new, proprietary co-spray dried MCC/mannitol excipient. The co-processing of MCC and mannitol creates a synergistic functionality, providing superior benefits versus the use of individual or dry-blended components. Avicel® HFE-102 offers improvements in flow, compaction, and disintegration properties compared to traditional MCC grades. The product also exhibits less sensitivity to lubrication.
Generic and alternative names
- Avicel® HFE Microcrystalline Cellulose and Mannitol
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Microcrystalline cellulose (INCI Name): MCC, cellulose gel;
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Mannitol: D-Mannitol, Manna sugar, 1,2,3,4,5,6-Hexanehexol
Claims / benefits / efficacy
Avicel® co-processed excipients offer improved:
- Improved flow and decreased lubrication sensitivity
- Powder flow
- Content uniformity
- Tablet compactibility
- Lubrication tolerance
- Sensory attributes in chewables
- Suspension properties in liquids
- Highly suitable for continuous manufacturing
Function
- Filler
- Diluent
Application
Key applications:
- Direct Compression
- Dry Granulation
Grades
Available Grades Particle Size, μm Moisture, % Differentiating Features Avicel® HFE-102 100 NMT 5.0 Improved porder flow and low lubricant sensitivity