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Avicel® HFE-102

Avicel® HFE-102

Microcrystalline Cellulose, NF, Ph. Eur., JP and mannitol, USP, Ph. Eur., JP

Avicel® HFE-102 is a new, proprietary co-spray dried MCC/mannitol excipient. The co-processing of MCC and mannitol creates a synergistic functionality, providing superior benefits versus the use of individual or dry-blended components. Avicel® HFE-102 offers improvements in flow, compaction, and disintegration properties compared to traditional MCC grades. The product also exhibits less sensitivity to lubrication.

  • Generic and alternative names

    • Avicel® HFE Microcrystalline Cellulose and Mannitol
    • Microcrystalline cellulose (INCI Name): MCC, cellulose gel;

    • Mannitol: D-Mannitol, Manna sugar, 1,2,3,4,5,6-Hexanehexol

  • Claims / benefits / efficacy

    Avicel® co-processed excipients offer improved:

    • Improved flow and decreased lubrication sensitivity
    • Powder flow
    • Content uniformity
    • Tablet compactibility
    • Lubrication tolerance
    • Sensory attributes in chewables
    • Suspension properties in liquids
    • Highly suitable for continuous manufacturing
  • Function

    • Filler
    • Diluent
  • Application

    Key applications:

    • Direct Compression
    • Dry Granulation
  • Grades

    Available Grades Particle Size, μm Moisture, % Differentiating Features
    Avicel® HFE-102 100 NMT 5.0 Improved porder flow and low lubricant sensitivity
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