Avicel® (SMCC)
Microcrystalline Cellulose Colloidal Silicon Dioxide (SMCC) NF, JP, Ph. Eur.
Avicel® SMCC is a high functionality co-processed spray-dried excipient comprising of 98 percent of microcrystalline cellulose (MCC) and 2 percent of colloidal silicon dioxide. Silicification reduces cohesiveness of the powder blend thus enhancing flow properties compared to MCC. It increases the surface area, which improves the binding properties of MCC. It also results in better compactibility, provides excellent homogeneity and content uniformity even for low-dosed, micronized active ingredients.
Generic and alternative names
- Avicel® Microcrystalline Cellulose Colloidal Silicon Dioxide (SMCC)
Claims / benefits / efficacy
Features and benefits:
- Optimum flow
- Superior compactibility
- Excellent binding properties
- Greater ease of blending
- Increased content uniformity
- Improved lubrication tolerance
- Less material wastage
- Allows for robust formulations with fewer ingredients
- Greater ease of scale-up
- Reduced manufacturing costs
- Highly suitable for continuous manufacturing
Function
- Filler
- Diluent
- Dry Binder
Application
- Powders
- Granules
- Tablets
Diluent and Dry Binder for MUPS, filler-binder for DC
Grades
Available Grades Particle Size, μm Bulk density, g/mL Differentiating Features Avicel® SMCC 50 45 - 80 0.25 - 0.37
Improved powder flow and increased compactibilityAvicel® SMCC 90 90 - 150 0.25 - 0.37
Improved powder flow and reduced tablet variabilityAvicel® SMCC HD 90 90 - 160 0.38 - 0.50 Improved powder flow, reduced tablet variability, higher bulk density