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Cellactose® 80

Cellactose® 80

Cellactose® 80
Lactose and Cellulose are very well established excipients. Both are naturally derived and frequently used as diluent/binder in oral dosage formulations (ODT).
In an effort to obtain synergistic effects, such as improved tablet hardness and adherence capacity, by co-processing both excipients, spray-drying was used in order to bring lactose and cellulose together.
As a result Cellactose® 80, a co-processed excipient, was achieved that provides capability for direct compression, due to given flowability and compactability. Cellactose® 80 is made up of 75 % alpha-Lactose-monohydrate and 25 % powdered cellulose.
Particle size distribution
[Air jet sieve]
<32 µm: NMT 20%
<160 µm: 35-65%
<250 µm: NLT 80%
Typical Values
Bulk Density [g/l]: 370
Tapped Density [g/l] : 490
Hausner factor: 1.32
Carrs index: 24.49 %
  • INCI

  • Generic and alternative names

    Compound of Lactose Monohydrate and Powdered Cellulose
  • Claims / benefits / efficacy

    Good content uniformity due to low segregation tendency of the active ingredient Smooth surface of the resulting cores for easy and economical coating Compaction of delicate active ingredients due to excellent compactability Consistent tablet hardness through constant lactose/cellulose ratio High weight consistency at all compaction speeds
  • Function

    diluents; fillers
  • Application

    Cellactose® 80 is primarily designed for direct compression. In comparison with its corresponding physical blend. Cellactose® 80 provides improved tablet hardness, superior flowability and adherence capacity that prevents segregation of blended API and excipient. Due to its adherence capacity Cellactose® 80 can be used in low dosage formulations. Cellactose® 80’s superior hardness yield enables its use in high dosage formulations, as well.
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