High-functionality excipient CombiLac® is an integrated, lactosebased, co-processed excipient, specifically designed to ease oral solid dosage form development and manufacture. It comprises 70 % alpha-lactose monohydrate, 20 % microcrystalline cellulose (MCC) and 10 % white, native corn starch, each conforming with Ph.Eur., USP-NF, and JP compendial requirements.
The three individual components are integrated into a monoparticulate structure, which is not separable by physical means. CombiLac® shows improved compaction properties compared to an equivalent admixture of individual ingredients, providing robust tablets with minimal friability.
It assures rapid, hardness-independent tablet disintegration for effective API release, and features powder flow characteristics necessary to enhance dosage form weight uniformity and throughput in DC.
Particle size distribution
[Air jet sieving]
< 32 µm: NMT 15%
< 160 µm: 35 - 65%
< 250 µm: NLT 85%
Typical Values
Bulk Density [g/l]: 450
Tapped Density [g/l] : 540
Angel of repose: 30 °
Hausner factor: 1.19
Carrs index: 16 %
