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MicroceLac® 100

MicroceLac® 100

Lactose and microcrystalline cellulose are very well established excipients. Both are naturally derived and used frequently as diluents/binder in oral dosage formulations (ODT).
In a effort to obtain synergistic effects, such as improved tablet hardness and adherence capacity, by combining both excipients, spray-dyring was used in order to bring Lactose and Microcrystalline cellulose together. As a result MicroceLac® 100, a co-processed excipient, was achieved, that provides capability for direct compression, due to given flowability and compactability.
MicroceLac® 100 comprises 75 % alpha-lactose monohydrate and 25 % microcrystalline cellulose (MCC), both maintaining their individual chemical identities.
Particle size distribution
[Air jet sieve]
<32 µm: NMT 15%
<160 µm: 45-70%
<250 µm: NLT 90%
Typical Values
Bulk Density [g/l]: 460
Tapped Density [g/l] : 580
Hausner factor: 1.26
Carrs index: 20.69 %
  • INCI

  • Generic and alternative names

    Compound of Lactose Monohydrate and Microcrystalline cellulose
  • Claims / benefits / efficacy

    Good content uniformity due to low segregation tendency of the active ingredient Smooth surface of the resulting cores for easy and economical coating Compaction of delicate active ingredients due to excellent compactability Consistent tablet hardness due to constant lactose/cellulose ratio High weight consistency at various tabletting speed.
  • Function

    diluents; fillers
  • Application

    MicroceLac® 100 is primarily designed for direct compression. In comparison with its corresponding physical blend MicroceLac® 100 provides improved tablet hardness, superior flowability and higher adherence capacity, that prevents segregation of a blended API and excipient. Due to its adherence capacity MicroceLac® 100 can be used in low dosage formulation. MicroceLac® 100’s superior hardness yield enables its use in high dosage formulations as well.
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