Protanal® LFR 5/60
Protanal LFR 5/60 is a low molecular weight (low viscosity) sodium alginate derived from Laminaria hyperborean, a type of marine brown algae. Its cold solubility allows it to form relatively weak gels when combined with calcium. The primary application of Protanal LFR 5/60 lies in liquid esophageal reflux formulations.
Alginate, a natural hydrocolloid found in marine brown algae, serves as an effective barrier for gastroesophageal reflux disease (GERD). When alginate enters the stomach, it interacts with gastric juice, creating a long-lasting acid gel that acts as a physicochemical barrier between the stomach and the esophagus. This prevents the stomach acid from entering the esophagus, providing relief from GERD symptoms. Additionally, increased intra-gastric pressure causes the alginate foam to rise into the lower esophagus and adhere to the mucosa, forming a protective coating against the acidic stomach contents.
Protanal LFR 5/60 is particularly recommended for creating premier raft formations in liquid products, and it also serves as a solubilizer for solid-dispersion and nano-dispersion. The key dosage forms for this sodium alginate are oral suspensions and chewable tablets, making it a valuable ingredient in pharmaceutical and medical applications. Overall, sodium alginate is derived from brown seaweed and is known for its efficacy in treating GERD, owing to its ability to create a strong physical barrier, preventing stomach acid from entering the esophagus.
Generic and alternative names
- Alginic acid
- Sodium salt
Claims / benefits / efficacy
- Cold and hot water solubility
- Viscosity, gelation and rheology-modification at low concentration
- Gelation with calcium source (no need for heat treatment i.e. cold-gelling)
- Suspending agent
- Water-binding / high water retention efficiency
- Rheology modifier/stabilizer
- Gelling agent
- Suspensions, Tablets
- Stabilization in solutions and suspensions
- Solid Dispersion
- Nano-suspension Stabilizer