Protanal® LFR 5/60

Protanal LFR 5/60 is a low molecular weight (low viscosity) sodium alginate derived from Laminaria hyperborean, a type of marine brown algae. Its cold solubility allows it to form relatively weak gels when combined with calcium. The primary application of Protanal LFR 5/60 lies in liquid esophageal reflux formulations.
 
Alginate, a natural hydrocolloid found in marine brown algae, serves as an effective barrier for gastroesophageal reflux disease (GERD). When alginate enters the stomach, it interacts with gastric juice, creating a long-lasting acid gel that acts as a physicochemical barrier between the stomach and the esophagus. This prevents the stomach acid from entering the esophagus, providing relief from GERD symptoms. Additionally, increased intra-gastric pressure causes the alginate foam to rise into the lower esophagus and adhere to the mucosa, forming a protective coating against the acidic stomach contents.
 
Protanal LFR 5/60 is particularly recommended for creating premier raft formations in liquid products, and it also serves as a solubilizer for solid-dispersion and nano-dispersion. The key dosage forms for this sodium alginate are oral suspensions and chewable tablets, making it a valuable ingredient in pharmaceutical and medical applications. Overall, sodium alginate is derived from brown seaweed and is known for its efficacy in treating GERD, owing to its ability to create a strong physical barrier, preventing stomach acid from entering the esophagus.