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Quatrefolic® is a nutrient designed for all areas where folic acid and supplementation has been recommended and allowed. The terms folic acid and folate are often used interchangeably for the water-soluble B-complex vitamin, essential for the maintenance of cellular functions and health.


Quatrefolic® provides the active form of folate, 5-methyltetrahydrofolate (5-MTHF), naturally present in the body and available for its biological action. It has significant advantages over previous folate generations while maintaining the same biological properties of 5-methyltetrahydrofolate. Compared to standard folic acid, Quatrefolic® doesn’t lead to accumulation of Unmetabolized Folic Acid (UMFA) in the blood, which has no biological function and whose effects are not yet known.


Based on a critical evaluation of the available data, and on relevant biological and toxicological studies, an independent expert panel confirmed that Quatrefolic® is generally recognised as safe (GRAS) for use as a source of folate in conventional and medical foods.

  • Generic and alternative names

    Generic name: Active Folate

    Chemical name: glucosamine salt of (6S)-5-methyltetrahydrofolate

  • Claims / benefits / efficacy

    •    > 99% purity and GRAS status.
    •    Quatrefolic® passes the gastric barrier and is absorbed mainly in the small intestine by a carrier mediated mechanism. The carrier is not saturated and this ensures a higher folate uptake.
    •    In children it can improve energy production and the formation of red blood cells while promoting normal brain development and function. Moreover, the 5-MTHF can boost learning ability and memory.
    •    Can bypass folate metabolism disturbances, improving fertility, and increasing success rates in infertility treatment.
    •    May be particularly useful to provide the nutritionally active form of folate during preconceptions, pregnancy and lactation.
    •    May help postmenopausal women to normalize homocysteine, contributing to helping hot flashes, cardiovascular and bone health of aging women.
    •    Offers a homocysteine-lowering and -normalizing effect clinically proven.
    •    May help reduce unbalanced mood symptoms.
    •    May help with Glucose metabolism.
    •    Is a Gnosis by Lesaffre proprietary product with patents and trademark applications guaranteeing a wide range of use and covering all areas of folate application.
    •    Is produced according to cGMP, guaranteeing a reproducible quality profile.
    •    Vegetarian (does not come from animal sources)

  • Function

    • Active ingredient
    • Supplement
  • Application

    • Can be used for combinations and formulations with vitamins and minerals, both for dietary supplements and Food & Beverage industry.
    • Tablets, capsules, and soft gels
    • Instant Drinks
    • Unconventional dosage formulations such as granular and powdered microencapsulated forms delivered in sachets and powder blends.
  • Packaging

    • 0,1 KG
    • 0,5 KG
    • 1 KG
    • 5 KG
  • Certifications & Compliance

    • Gluten-free
    • Halal
    • Kosher
    • Lactose-free
    • Non-GMO
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